The Texans are 3-1/2 point favorites over the Bills. This is the fifth meeting for the teams. Buffalo has dominated the series 3 – 1. Houston quarterback Mark Schaub leads the league with 2,074 yards and 16 touchdowns. Tight end Owen Daniels is having a standout year with 39 catches and 5 touchdowns. Ryan Fitzpatrick will start for the Bills. He has averaged only 120 yards in the last 2 games and completed less than 45 percent of his passes. The defense will have to force turnovers. Buffalo leads the NFL along with New Orleans in interceptions. The Bills are looking to extend their winning streak to 3 games. They would then be .500 at midseason.